GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs12220238 | 1 | rs4320897 | chr10:76017732 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.37 | 1.57E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs881375 | 1 | rs4323544 | chr9:123647377 | LOC253039 | chr9:123605320-123616644:+ | -0.34 | -5.81 | 1.3E-8 | Rheumatoid arthritis |
| BLCA | cis | rs10935120 | 1 | rs4334685 | chr3:134304335 | ANAPC13 | chr3:134196547-134204865:- | 0.48 | 7.6 | 2.33E-13 | Height |
| BLCA | cis | rs433598 | 1 | rs433598 | chr16:20680206 | ACSM1 | chr16:20634559-20709066:- | 0.21 | 3.99 | 7.85E-5 | Schizophrenia |
| BLCA | cis | rs9902453 | 1 | rs4350617 | chr17:28423088 | EFCAB5 | chr17:28256874-28435469:+ | 0.23 | 3.91 | 0.000109 | Coffee consumption (cups per day) |
| BLCA | cis | rs9783347 | 1 | rs4353250 | chr11:18323517 | GTF2H1 | chr11:18343816-18388590:+ | 0.31 | 5.88 | 8.86E-9 | Pancreatic cancer |
| BLCA | cis | rs9457247 | 1 | rs436707 | chr6:167388843 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.04 | 7.23E-7 | Crohn's disease |
| BLCA | cis | rs10935120 | 1 | rs4367113 | chr3:134287975 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.81 | 5.66E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs4367113 | chr3:134287975 | CEP63 | chr3:134204575-134293852:+ | 0.22 | 3.83 | 0.00015 | Height |
| BLCA | cis | rs10935120 | 1 | rs4368544 | chr3:134300014 | ANAPC13 | chr3:134196547-134204865:- | -0.5 | -7.94 | 2.24E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs4368544 | chr3:134300014 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.14 | 4.32E-5 | Height |
| BLCA | cis | rs4372836 | 1 | rs4372836 | chr2:28973883 | TRMT61B | chr2:29072690-29093175:- | -0.29 | -5.13 | 4.54E-7 | Body mass index |
| BLCA | cis | rs8072100 | 1 | rs4375701 | chr17:45712218 | C17orf57 | chr17:45401142-45518675:+ | 0.25 | 5.57 | 4.69E-8 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs2275426 | 1 | rs4376778 | chr1:46288846 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs2243480 | 1 | rs437889 | chr7:65509234 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.38 | 1.51E-5 | Diabetic kidney disease |